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Interstate 64 (I-64) passes through the Greater St. Louis area in the U.S. state of Missouri. The entire route overlaps U.S. Route 40 (US 40). Because the road was a main thoroughfare in the St. Louis area before the development of the Interstate Highway System, it is not uncommon for locals to refer to the stretch of highway as \...Full Wikipedia Topic
Highway I-64 runs West to East with exit numbers starting at the western most exit of each state or province.
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